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873786-09-5
Formula: C12H15N3O2
SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages
pii: S0006-2952(16)30380-X
and peak plasma concentration was 58 μM
ABC294640 - CAS# 915385-81-8 Catalog No.:M6465-10 873786-09-5ABC294640, also known as Opaganib, CAS No. 915385 81 8, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase 2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro apoptotic amino alcohol sphingosine to sphingosine 1 phosphate (S1P), the lipid mediator that is pro survival and critical for
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